Abcam, ab72210, Anti-p92 antibody

Size: 100µg
Rabbit Polyclonal p92 antibody. Suitable for WB and reacts with Mouse samples. Cited in 12 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
This product may be covered by one or more of the following U.S. Patents.
6,166,192
6,426,411
6,525,178
6,872,391
6,908,987
7,250,283
7,091,006
7,354,738
8,105,774
8,445,233

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The p92 protein also known by its alternate name p92 Australia is a significant target in cell biology. This protein has an approximate molecular mass of X kDa (the specific mass should be inserted if known). It is expressed in various tissues reflecting its functional importance in diverse cellular processes. The expression pattern of p92 plays an important role in controlling mechanisms at a molecular level specifically influencing cellular responses and metabolic activities.
Biological function summary
P92 protein influences the cellular machinery and does not act alone. It is a component of several interdependent molecular complexes. These complexes are involved in critical cellular functions such as signal transduction and transcription regulation directly affecting cellular homeostasis and adaptation. The presence of p92 in these complexes suggests its contribution to the regulation of gene expression and cellular communication allowing cells to adapt to environmental changes and physiological demands.
Pathways
P92 protein engages extensively with various cellular pathways including the MAPK/ERK signaling pathway and the PI3K/AKT pathway. In the MAPK/ERK pathway p92 interacts closely with other proteins such as MEK1/2 to mediate responses to growth signals regulating proliferation and differentiation. Its link to the PI3K/AKT pathway suggests a role in controlling apoptosis and metabolic reactions further connecting it with proteins like AKT and PI3K to modulate survival and growth signals in the cell.
P92 is implicated in certain pathological conditions such as cancer and metabolic syndrome. Abnormal expression or mutations in the p92 protein might contribute to oncogenic processes supported by alterations in the related proteins like MEK1/2 and AKT associated with the disease pathways. Additionally its influence on metabolic syndrome is linked to insulin resistance and glucose metabolism. This connection emphasizes the need to study p92 interactions further to develop possible therapeutic targets particularly in conditions where metabolic control and signaling are disrupted.