Abcam, ab72223, Anti-GMAP-210 antibody

Size: 100µL
Rabbit Polyclonal GMAP-210 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TRIP11 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIP11 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q15643

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab72223 was affinity purified using an epitope specific to GMAP-210 immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GMAP-210 also known as Trip11 is a large coiled-coil protein with a molecular weight of approximately 228 kDa. It primarily functions as a Golgi microtubule-associated protein playing a role in the structural integrity and organization of the Golgi apparatus. This protein is expressed in cells across various tissues highlighting its important role in maintaining proper cellular operations.
Biological function summary
GMAP-210 assists in vesicle tethering and trafficking processes ensuring the effective movement of proteins and lipids along the secretory pathway. It is not part of any large protein complex but interacts with other Golgi-associated proteins to stabilize microtubules and Golgi membranes. Its interactions are key for the correct sorting and delivery of proteins to their destinations within cells making it integral to maintaining cellular membrane dynamics.
Pathways
GMAP-210 functions significantly within the secretory pathway. It interacts with proteins essential for Golgi transport such as Golgin-84 to mediate the movement of vesicles between the Golgi stacks and other cellular compartments. Additionally GMAP-210 has roles in the regulation of the microtubule network which is vital for intracellular transport and cellular morphology maintenance.
Defects in the GMAP-210 protein are linked to achondrogenesis type 1A and can also contribute to other skeletal dysplasias. It is associated with collagen processing errors due to its role in Golgi transport which can lead to structural protein accumulation. These disorders highlight the importance of GMAP-210's interaction with proteins like collagen in maintaining normal skeletal development and function.