Abcam, ab72455, Anti-TR150 antibody

Size: 100µL
Rabbit Polyclonal TR150 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human THRAP3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human THRAP3. The exact immunogen used to generate this antibody is proprietary information.Q9Y2W1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TR150 also known as Transcription Regulator 150 is a protein with a molecular mass of approximately 150 kDa. You can find its expression in various tissues with higher levels in liver and brain tissues. Mechanically TR150 acts as a transcriptional regulator and binds directly to DNA to modulate the expression of different genes. Its capability to bind specific DNA sequences allows it to influence gene transcription effectively.
Biological function summary
TR150 plays a critical role in regulating gene expression that affects cellular functions like cell cycle progression and cell differentiation. It functions as part of a transcriptional regulatory complex interacting with cofactors and other transcriptional regulators to fine-tune gene expression. Its activity impacts cellular growth and development indicating its integral role in maintaining cellular homeostasis.
Pathways
TR150 is involved in the cell cycle regulation pathway and the Wnt signaling pathway. In the cell cycle pathway TR150 works alongside proteins such as Cyclin D1 to control cell division. In the Wnt signaling pathway it interacts with β-catenin and influences the transcriptional activation of Wnt target genes. Through these pathways TR150 helps in the coordination of proliferative signals and gene expression patterns.
Altered expression of TR150 has been linked to cancer and neurodegenerative diseases. Overexpression or dysfunction in TR150 can disrupt normal cell cycle control contributing to oncogenesis. In neurodegenerative diseases abnormal TR150 expression may interfere with neuronal function and survival. In these contexts it connects to proteins like p53 in cancer pathways and Tau in neurodegenerative pathways highlighting its involvement in disease mechanisms.