Abcam, ab72550, Anti-RPL7 antibody

Size: 100µL
Rabbit Polyclonal RPL7 antibody. Suitable for IHC-P, IP, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 32 publications. Immunogen corresponding to Synthetic Peptide within Human RPL7.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RPL7. The exact immunogen used to generate this antibody is proprietary information.P18124

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL7 also known as Ribosomal Protein L7 is an important component of the 60S large ribosomal subunit and plays a fundamental role in protein synthesis. This protein weighs approximately 29 kDa and is involved in the formation and assembly of the ribosome. RPL7 is expressed in a wide range of tissues indicating its ubiquitous role in cellular processes. It interacts with RNA contributing to the stabilization and proper function of ribosomal units.
Biological function summary
RPL7 engages in ribosomal structure and function participating in the translation process. It is a part of the large ribosomal complex the 60S subunit which works in concert with 40S subunit during protein synthesis. RPL7 binds RNA and plays a role in aligning mRNA and tRNAs in the ribosome facilitating accurate translation and peptide bond formation. Additionally it contributes to the proper assembly of ribosomal proteins and RNA components.
Pathways
RPL7 plays a role in the translational control pathway and ribosome biogenesis pathway. It interacts with other ribosomal proteins such as RPL13 and RPL10A and is essential for the proper progression of these pathways which impact protein production necessary for cell growth and differentiation. RPL7's involvement in these pathways emphasizes its contribution to cellular protein balance and homeostasis.
Alterations in RPL7 are associated with cancer and ribosomopathies. Changes in RPL7 expression levels can disrupt normal ribosomal function leading to uncontrolled cell proliferation seen in various cancers with potential connections to tumor suppressor proteins like p53. Also ribosomopathies involving ribosomal defects link RPL7 to conditions such as Diamond-Blackfan anemia a rare genetic disorder affecting blood cell production. RPL7's function and interactions highlight its relevance in maintaining cellular and organismal health.