Abcam, ab72603, Anti-ELAVL2 + ELAVL4 antibody

Size: 100µg
Rabbit Polyclonal ELAVL2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ELAVL2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ELAVL2. The exact immunogen used to generate this antibody is proprietary information.Q12926

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELAVL2 and ELAVL4 also known as HuB and HuD are RNA-binding proteins with a molecular weight of approximately 36-42 kDa. These proteins are part of the ELAV (Embryonic Lethal Abnormal Vision) family playing an important role in the post-transcriptional regulation of gene expression. ELAVL2 and ELAVL4 are expressed predominantly in the neurons where they bind to AU-rich elements in the 3' untranslated regions of target mRNAs influencing their stability and translation.
Biological function summary
ELAVL2 and ELAVL4 stabilize mRNAs and modulate their translation. They participate actively in the neuronal differentiation processes and synaptic plasticity. The proteins do not typically form large complexes but instead work as vital regulators of neuronal mRNA. Their activity leads to the proper expression of target genes facilitating the development and function of the nervous system.
Pathways
RNA-binding proteins like ELAVL2 and ELAVL4 are involved in the regulation of neural pathways and synaptic communication. They play a major role in the mRNA processing and transport pathways. Furthermore they work closely with proteins such as FMRP (Fragile X Mental Retardation Protein) and other ELAV family members coordinating the stability of specific transcripts necessary for synaptic function and plasticity.
ELAVL2 and ELAVL4 show significant relevance to neurodegenerative diseases and cancer. Altered expression or malfunction of these proteins directly impacts conditions like Alzheimer's disease and certain types of neural tumors. These proteins' association with dysfunctional mRNA processing and regulation connects them to other disease-related proteins such as Tau in Alzheimer's highlighting their influence on pathogenesis.