Abcam, ab72730, Anti-DOK6 antibody

Size: 100µg
Rabbit Polyclonal DOK6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DOK6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DOK6. The exact immunogen used to generate this antibody is proprietary information.Q6PKX4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DOK6 known also as Docking Protein 6 is a member of the DOK family of proteins which are critical in intracellular signaling pathways. It weighs approximately 36 kDa and predominantly functions as an adaptor protein. Expression of DOK6 mainly occurs in the central nervous system particularly within neuronal tissues. It plays a fundamental role in the transmission of extracellular signals into the intracellular environment influencing various downstream effects.
Biological function summary
This protein supports neuronal differentiation and development. DOK6 does not operate alone but often combines with other proteins in signaling complexes. Its interactions enable it to regulate the signaling pathways that dictate neuronal survival growth and maturation. Research indicates that DOK6 influences cytoskeletal reorganization which is important for maintaining neuronal architecture and function.
Pathways
DOK6 serves as a significant player in the RET signaling pathway and possibly the Trk neurotrophin receptor pathway. It relates to proteins like RET and Shc contributing to these cascades. Through these pathways DOK6 assists in mediating the effects of growth factors that are essential for the growth and repair of the nervous system.
Studies have linked DOK6 to neurodevelopmental disorders and certain types of cancer. Abnormal DOK6 expression or function often correlates with conditions like Hirschsprung's disease where it interacts with RET. Research into its exact roles in these diseases continues providing hope for new therapeutic strategies.