Abcam, ab73113, Anti-LRSAM1 antibody

Size: 50µg
Mouse Polyclonal LRSAM1 antibody. Suitable for WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LRSAM1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human LRSAM1.Q6UWE0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRSAM1 also known as Leucine-rich repeat and Sterile Alpha Motif-containing protein 1 functions mechanically as an E3 ubiquitin ligase. It plays an important role in tagging proteins for degradation. The protein mass of LRSAM1 is approximately 82 kDa. This protein expresses across various tissues with notable presence in the central nervous system including neurons. LRSAM1 also interacts within the cytoplasm and nucleus influencing multiple cellular processes.
Biological function summary
LRSAM1 contributes critically to the regulation of protein homeostasis. It does not form a known large multimeric complex but may interact closely with other components in the ubiquitination machinery. This process is significant for cellular control of protein turnover affecting cellular signaling and response to stress. LRSAM1 assists in maintaining protein quality by marking damaged or unnecessary proteins for destruction.
Pathways
LRSAM1 regulates protein turnover through its role in the ubiquitin-proteasome system. It influences pathways related to protein quality control and signal transduction. In these pathways LRSAM1 shows interactions with proteins such as ubiquitin and proteasomal subunits. This connects LRSAM1 to cellular mechanisms that monitor and regulate cell cycle apoptosis and response to oxidative stress.
Mutations or dysregulation of LRSAM1 relate to Charcot-Marie-Tooth disease type 2P and some forms of neurodegenerative disorders. Charcot-Marie-Tooth disease type 2P stems from mutations in LRSAM1 affecting peripheral nerve function. The protein's involvement with disorders like these highlights its connection to cellular stress responses. LRSAM1 links to proteins involved in mitochondrial function emphasizing its role in maintaining neural health and function.