Abcam, ab73287, Anti-CPEB1 antibody

Size: 100µg
Rabbit Polyclonal CPEB1 antibody. Suitable for WB, ICC/IF and reacts with Rat samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human CPEB1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CPEB1. The exact immunogen used to generate this antibody is proprietary information.Q9BZB8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) functions mechanically as a regulator of mRNA translation. Often referred to simply as CPEB1 this protein has a mass of approximately 62 kDa. CPEB1 is expressed in various tissues including the brain and ovary indicating its role in diverse physiological processes. It binds to the cytoplasmic polyadenylation element typically found at the 3' untranslated region of mRNAs controlling the length of the poly(A) tail and therefore influencing mRNA stability and translation.
Biological function summary
CPEB1 regulates cell cycle progression synaptic plasticity and gametogenesis. This protein sometimes part of larger ribonucleoprotein complexes acts by coordinating the temporal and spatial translation of target mRNAs. In neurons CPEB1 plays a significant role in the regulation of local protein synthesis impacting synaptic function and plasticity. In reproductive biology it influences oocyte maturation by modulating the translation of mRNAs important for meiotic progression.
Pathways
CPEB1 plays critical roles within pathways associated with long-term potentiation and the cell cycle. In the long-term potentiation pathway CPEB1 works alongside proteins such as eIF2α to enhance synaptic strength and memory formation. In cell cycle regulation CPEB1 affects the translational activation of cyclins thereby controlling the progression through the cell cycle phases. These pathways highlight its involvement in maintaining cellular homeostasis and response to external stimuli.
CPEB1 has been implicated in neurological disorders such as Alzheimer's disease and Fragile X syndrome. In Alzheimer's disease dysregulation of CPEB1 can lead to impaired synaptic function exacerbating cognitive decline. Similarly CPEB1's interaction with FMRP links it to Fragile X syndrome where it influences synaptic plasticity and neuronal development. These associations highlight the importance of CPEB1 in brain health and cognitive functionality.