Abcam, ab73352, Anti-ACSF3 antibody

Size: 50µg
Mouse Polyclonal ACSF3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ACSF3.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ACSF3.Q4G176

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACSF3 also known as acyl-CoA synthetase family member 3 is involved in converting free fatty acids into fatty acyl-CoA esters which are necessary for various metabolic processes. The ACSF3 protein has a molecular mass of approximately 64 kDa and is expressed in mitochondria within cells. It plays a particularly important role in the liver where it assists in lipid metabolism and energy production. The presence of this protein is important for cells that require efficient fatty acid processing.
Biological function summary
This protein contributes to cellular energy homeostasis and lipid biosynthesis. ACSF3 is not part of a known protein complex. However it functions effectively in the mitochondrial environment where it integrates with other metabolic processes. This protein is involved in the generation of substrates for the tricarboxylic acid cycle highlighting its importance in energy metabolism.
Pathways
ACSF3 plays a significant role in fatty acid metabolism and energy production within cells. It participates in the fatty acid oxidation pathway where it helps in the activation and breakdown of fatty acids providing an essential fuel source for the body. ACSF3 is related to the protein CPT1A which is another key player in the fatty acid oxidation pathway facilitating the transport of fatty acids into mitochondria for oxidation.
ACSF3 is linked with combined malonic and methylmalonic aciduria a metabolic disorder characterized by the accumulation of malonic and methylmalonic acids in the body. Mutations in ACSF3 can disrupt normal enzyme function leading to this condition. Additionally ACSF3 has potential implications in lipid-related disorders and is examined in relation to proteins such as MUT whose deficiencies are also associated with methylmalonic aciduria.