Abcam, ab74049, Anti-GNAL antibody

Size: 100µg
Rabbit Polyclonal GNAL antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human Guanine nucleotide-binding protein G(olf) subunit alpha aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Guanine nucleotide-binding protein G(olf) subunit alpha aa 50-100. The exact immunogen used to generate this antibody is proprietary information.P38405

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The GNAL gene encodes a protein also known as guanine nucleotide-binding protein G(olf) subunit alpha. This protein with a mass of approximately 45 kDa is part of the G-protein family that couples with G-protein-coupled receptors (GPCRs). GNAL is mainly expressed in the brain particularly in the olfactory system and basal ganglia. It plays a role in signal transduction processes by modulating signaling pathways initiated by neurotransmitter receptors.
Biological function summary
Proteins encoded by GNAL participate in signal transduction pathways. These pathways often engage G-protein complexes where GNAL functions as the alpha subunit. It initiates the activation of intracellular signaling cascades upon interaction with activated receptors. GNAL contributes to neurotransmitter signaling which has implications in sensory perception a function dependent on the proper relay of chemical signals within the nervous system.
Pathways
GNAL focuses on neurotransmission and sensory processing. It significantly affects the dopamine signaling pathway important for motor control and reward-motivated behaviors. In this pathway GNAL interacts with dopamine receptors to mediate signal transduction working alongside other proteins such as DRD1. Additionally GNAL is involved in the olfactory transduction pathway important for detecting and processing odors emphasizing its specific expression in the olfactory bulb.
Defects or mutations in GNAL correlate with certain neurological disorders. They are linked to Dystonia where abnormal muscle contractions lead to twisting and repetitive movements. This connection occurs through altered GNAL-mediated dopamine signaling affecting DRD1 functions. Furthermore GNAL variants associate with schizophrenia owing to disruptions in neurotransmission pathways. Understanding the role of GNAL offers insights into its involvement in diseases related to dopamine pathway dysfunctions.