Abcam, ab74333, Anti-FAM175B antibody

Size: 100µL
Rabbit Polyclonal FAM175B antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ABRAXAS2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ABRAXAS2. The exact immunogen used to generate this antibody is proprietary information.Q15018,
Specificity:The antibody recognises a region between residue 350 and 390 of human FAM175B using the numbering given in entry NP_115558.3 (GeneID 23172).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibody was affinity purified using an epitope specific to FAM175B immobilized on solid support., Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM175B also known as ABRAXAS2 is a protein with a molecular weight of approximately 42 kDa. It plays an important role in DNA repair processes. Expression of FAM175B is observed in various tissues with notable presence in the nucleus due to its involvement in DNA damage response. The protein has a significant presence in actively dividing cells where maintenance of genomic integrity is essential.
Biological function summary
FAM175B is part of the BRCA1 A complex which is an important player in homologous recombination repair. This complex helps in recognizing and repairing double-strand breaks in DNA a critical function for preventing genomic instability. FAM175B directly interacts with other components of this complex such as BRCA1 and RAP80 ensuring precise repair of DNA. The protein acts as a scaffold coordinating protein-protein interactions necessary for complex formation and function.
Pathways
FAM175B is an indispensable component of the DNA damage response and repair pathway. This pathway is paramount for cellular resistance to DNA-damaging agents. FAM175B functions alongside BRCA1 and other associated proteins like RAD51 to facilitate repair processes. It links the recognition of DNA lesions with the execution of DNA repair playing a pivotal role in maintaining cellular health.
FAM175B has a significant association with breast cancer susceptibility. Mutations or malfunctions within the BRCA1 A complex where FAM175B operates can escalate risks for developing breast cancer. Additionally FAM175B is indirectly connected to ovarian cancer through its interactions with BRCA1. Its dysfunction in these pathways contributes to impaired DNA repair leading to tumorigenesis in these tissues.