Abcam, ab74454, Anti-ARHGAP17 antibody

Size: 100µg
Rabbit Polyclonal ARHGAP17 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ARHGAP17 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ARHGAP17 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q68EM7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP17 also known as Rho GTPase-activating protein 17 or by its popular alternate name Rich1 plays a significant role in regulating the Rho GTPase signaling pathway. It belongs to a group of proteins that convert active GTP-bound Rho GTPases to their inactive GDP-bound state. ARHGAP17 has a molecular weight of approximately 82 kDa. It is expressed in various tissues including the brain and the endothelial cells indicating its importance in diverse cellular environments.
Biological function summary
ARHGAP17 participates in cellular processes that require regulation of the actin cytoskeleton. It forms part of a larger complex that controls cell shape and movement by modulating cytoskeletal dynamics. By converting GTP-bound RhoA to its GDP-bound form ARHGAP17 directly affects cell morphology and polarity impacting processes like cell migration and adhesion.
Pathways
ARHGAP17 is actively involved in the Rho GTPase cycle which is critical for actin cytoskeleton reorganization. It intersects with the tight junction pathway where it influences cell-cell adhesion and maintains epithelial cell integrity. ARHGAP17 interacts with proteins such as Cdc42 enhancing its capacity to regulate cellular architecture and function within these pathways.
ARHGAP17 has been associated with conditions like cancer and cardiovascular disease. Aberrant expression or mutations of ARHGAP17 can lead to disruptions in cell polarity and uncontrolled cell proliferation contributing to tumor development. Moreover its role in maintaining endothelial cell junctions links it to cardiovascular disorders where it interacts with proteins like VE-cadherin to regulate vascular integrity.