Abcam, ab74544, Anti-OVGP1/OGP antibody

Size: 100µg
Rabbit Polyclonal OVGP1/OGP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human OVGP1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human OVGP1. The exact immunogen used to generate this antibody is proprietary information.Q12889

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OVGP1 also known as oviductal glycoprotein or OGP is a glycoprotein with a molecular mass around 120 kDa. This protein is expressed mainly in the oviduct epithelium in mammals. It is secreted during the peri-ovulatory phase and associates with the zona pellucida and the oocyte. OGP products are studied extensively due to their role in reproductive biology especially concerning fertilization and early embryonic development.
Biological function summary
OVGP1 plays an important role in reproduction. It interacts with the zona pellucida and helps facilitate sperm binding and penetration enhancing fertilization potential. The protein is not part of a large complex but is known for modifying the environment in the oviduct to support fertility. It also maintains the stability and permeability of the oocyte and embryo matrix impacting early stages of embryo development.
Pathways
OVGP1 influences reproductive pathways that involve sperm-egg interaction and embryo transport. The glycoprotein acts along pathways connected to fertilization affecting the zona pellucida's structural and functional properties which are also influenced by proteins like ZP3 (zona pellucida glycoprotein 3). These pathways ensure that the conditions in the oviduct are optimal for successful conception and embryo support.
OVGP1 has been linked to infertility and reproductive challenges. Altered expression or dysfunction of this protein can affect fertility contributing to conditions like fallopian tube disorders and ectopic pregnancies. It might also interact with other proteins related to infertility such as inhibin affecting its pathways and mechanisms. Understanding these interactions provides insight into the treatment and management of reproductive health issues.