Abcam, ab74681, Anti-ABHD6 antibody

Size: 100µg
Rabbit Polyclonal ABHD6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ABHD6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ABHD6. The exact immunogen used to generate this antibody is proprietary information.Q9BV23

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABHD6 also known as Alpha/Beta-Hydrolase Domain-Containing Protein 6 is a serine hydrolase enzyme with a molecular weight of around 40 kDa. This protein is expressed predominantly in the brain with presence also in other tissues such as the liver lungs and immune cells. Mechanically ABHD6 functions by hydrolyzing the lipid monoacylglycerol particularly 2-arachidonoylglycerol (2-AG) which is an endocannabinoid. By doing this ABHD6 plays a critical role in regulating lipid signaling pathways.
Biological function summary
ABHD6 affects endocannabinoid signaling by breaking down 2-AG into arachidonic acid and glycerol. This process positions ABHD6 as an essential regulator of cellular lipid balance and signaling. It is not typically part of a larger complex; ABHD6 operates mainly as a single enzyme. However its interaction with lipids impacts diverse cellular mechanisms including those related to metabolism and neural activity.
Pathways
The enzyme significantly affects the endocannabinoid and lipid metabolism pathways. ABHD6 is involved in modulating the levels of 2-AG influencing neurotransmission and inflammation. It sits within the same metabolic framework as other enzymes like monoacylglycerol lipase (MAGL) and diacylglycerol lipase both of which are important in the lipid signaling pathway. These interactions emphasize the role of ABHD6 in maintaining cellular homeostasis and influencing various physiological processes through lipid metabolism.
ABHD6 is associated with neurological disorders such as epilepsy and Alzheimer's disease. Alterations in ABHD6 expression or activity can lead to dysregulated endocannabinoid signaling which influences the severity and progression of these conditions. Furthermore ABHD6 is connected to neuroinflammation alongside proteins such as COX-2 which also participates in the inflammatory response. The understanding of ABHD6's role in these diseases could open new therapeutic avenues targeting lipid signaling pathways.