Abcam, ab74871, Anti-MPC1 antibody

Size: 100µg
Rabbit Polyclonal MPC1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human MPC1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MPC1. The exact immunogen used to generate this antibody is proprietary information.Q9Y5U8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The mitochondrial pyruvate carrier 1 (MPC1) also known as BRP44L is part of the MPC complex that facilitates pyruvate transport into mitochondria. This protein has a mass of approximately 15 kDa. MPC1 is expressed in various tissues with high metabolic demand including the liver heart and muscle. These tissues rely on effective pyruvate metabolism for energy production which highlights MPC1’s importance in cellular respiration and metabolic processes.
Biological function summary
MPC1 forms an important component of the MPC complex functioning alongside MPC2 to enable pyruvate import into mitochondria where it aids in energy production through the Krebs cycle. This import is essential for maintaining the balance of cellular metabolism and supporting ATP generation. The MPC1 complex has garnered interest due to its involvement in mitochondrial function and energy homeostasis important for cellular metabolism.
Pathways
MPC1 involvement centers on the integration of glycolysis and the tricarboxylic acid cycle. This protein provides a critical link for pyruvate conversion into acetyl-CoA influencing oxidative phosphorylation. MPC1 connects with other proteins like MPC2 forming a critical transport system. Alteration in the activity of these pathways can impact cellular energy levels and metabolic homeostasis highlighting its relevance in intermediary metabolism.
Mutations or dysfunctions in MPC1 have been associated with metabolic syndromes such as lactic acidosis and diabetes. The aberrant function of MPC1 in these conditions disrupts normal pyruvate metabolism leading to metabolic imbalance. In relation to diabetes MPC1’s interplay with insulin signaling pathways draws attention to its indirect role in the development of insulin resistance further connecting it to disorders involving energy dysregulation.