Abcam, ab75005, Anti-CEP135 antibody

Size: 100µg
Rabbit Polyclonal CEP135 antibody. Suitable for ELISA, WB, ICC/IF and reacts with Mouse, Human samples. Cited in 36 publications. Immunogen corresponding to Synthetic Peptide within Human CEP135.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:ELISA, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CEP135. The exact immunogen used to generate this antibody is proprietary information.Q66GS9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP135 also known as centrosomal protein 135kDa is an important structural component of the centrosome an important cellular organelle responsible for organizing microtubules during cell division. The protein has a molecular mass of approximately 135 kDa. It localizes mainly to the centrosome appearing in various cell types where it assists in the maintenance of centrosome integrity. Its expression is not limited to a single tissue; instead it occurs broadly underlining its importance in cellular processes reliant on centrosome function.
Biological function summary
CEP135 belongs to the percentriolar matrix where it plays a role in centrosome cohesion and spindle formation during mitosis. The protein contributes significantly to the assembly of the centrosomal complex working in concert with other structural proteins. Within this complex it acts to ensure the centrosome can correctly duplicate and segregate essential steps for accurate cell division and maintenance of genomic stability.
Pathways
CEP135 engages in the microtubule nucleation pathway and participates in bipolar spindle assembly both fundamental for cell division. Its function aligns closely with other centrosomal proteins such as γ-tubulin that are critical for the initiation and organization of microtubules. CEP135's activity must align with these pathways to facilitate correct chromosomal alignment and segregation a process essential for avoiding aneuploidy.
CEP135 connects mainly to microcephaly and some forms of cancer. Mutations in the CEP135 gene can lead to microcephaly a condition characterized by reduced brain size due to defective neurogenesis. This situation implicates CEP135's importance in brain development. Additionally CEP135's role in ensuring accurate segregation of chromosomes can influence cancer progression where centrosome defects and chromosomal instability are common. Relations with proteins like pericentrin highlight the broader implications of CEP135's dysfunction in pathological states.