Abcam, ab75061, Anti-INSL4 antibody

Size: 100µg
Rabbit Polyclonal INSL4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Early placenta insulin-like peptide.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Early placenta insulin-like peptide. The exact immunogen used to generate this antibody is proprietary information.Q14641

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab75061 was purified using an epitope-specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INSL4 also known as insulin-like 4 is a protein with a mass of approximately 15.8 kDa. This protein originates within the insulin superfamily and functions mechanically by playing a role in cell signaling. INSL4 exhibits expression mainly in placenta-related tissues suggesting its involvement in pregnancy-related processes. It differs from other insulin-like peptides in terms of both its sequence and specific roles in reproduction.
Biological function summary
INSL4 takes part in regulating placental development and can influence trophoblast differentiation. This protein operates independently rather than as a component of larger protein complexes. In early pregnancy INSL4 contributes to fetal tissue formation and influences cellular growth and differentiation. This makes INSL4 an important marker and functional molecule in embryonic development contexts.
Pathways
INSL4 joins several critical signaling cascades related to cell growth and differentiation. The protein is a participant in the insulin signaling pathway and can interact with receptors similar to those recognized by insulin and insulin-like growth factors. Additionally INSL4 connects with IGF1 and IGF2 in these pathways highlighting its role in tissue development and metabolic regulation.
INSL4 links to conditions such as pregnancy-related trophoblastic disease and certain types of cancer. Its aberrant expression or function may lead to complications during pregnancy or contribute to the progression of malignant cells. In trophoblastic diseases INSL4 might interact with proteins like hCG while in cancer connections with oncogenes such as ERK or PI3K signaling components might occur. Understanding these associations can shed light on potential biomarker or therapeutic roles for INSL4 in clinical settings.