Abcam, ab75882, Anti-OLFML2A antibody

Size: 100µg
Rabbit Polyclonal OLFML2A antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OLFML2A also known as Noelin-2 is a protein encoded by the OLFML2A gene. This protein weighs approximately 54 kDa and exhibits expression in various tissues including the brain and retina. OLFML2A belongs to the olfactomedin domain-containing protein family contributing to its potential role in cellular mechanisms like cell adhesion or differentiation. Researchers observe it in different developmental stages signifying its involvement in various cellular processes across the organism.
Biological function summary
OLFML2A contributes to maintaining extracellular matrix structure through interactions with other proteins. It is not known to be part of a larger protein complex but exerts its biological effects through interactions at the molecular level. The protein is involved in neural network formations and may influence synaptic architecture potentially impacting brain function. Despite its importance the exact biological pathways of this protein are still under investigation.
Pathways
OLFML2A plays a role in the ECM-receptor interaction and focal adhesion pathways. These pathways are important for maintaining cellular structural integrity and communication. OLFML2A interacts with integrins and other ECM proteins facilitating cell signaling events that guide cellular responses to their environment. Through these interactions OLFML2A might influence the behavior of other proteins such as fibronectin and laminins which are significant in tissue development and repair mechanisms.
OLFML2A shows an association with conditions affecting neural function such as Alzheimer's disease and age-related macular degeneration. These disorders involve disruptions in neural networks and retinal structure respectively where OLFML2A's role in ECM organization might be altered. In Alzheimer's disease OLFML2A could be connected with amyloid precursor protein (APP) through disrupted neural pathways potentially influencing disease progression. Understanding OLFML2A's specific role in these conditions could offer insights into new therapeutic strategies.