Abcam, ab76015, Anti-CTNNA2 antibody [EPR1795]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal CTNNA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR1795,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNA2 also known as alpha-N-catenin is a protein that plays a mechanical role in cellular adhesion. This protein has a mass of approximately 102 kDa. CTNNA2 localizes at adherens junctions and is expressed in various tissues with a high prominence in the nervous system. It connects the actin cytoskeleton to cadherin complexes facilitating cell-cell interactions that are essential for maintaining tissue integrity.
Biological function summary
CTNNA2 contributes significantly to cellular signaling and structural maintenance. It forms part of the cadherin-catenin complex important in linking cadherins to the actin cytoskeleton. This complex supports the stability and function of cellular junctions enabling communication between cells and influencing cell shape and polarity. The protein's role in the nervous system suggests its involvement in synaptic connectivity and plasticity.
Pathways
CTNNA2 participates in the Wnt signaling and the actin cytoskeleton regulation pathways. These pathways are vital for cellular growth differentiation and motility. In the Wnt signaling pathway CTNNA2 interacts with beta-catenin to regulate gene transcription and cell fate decisions. Its involvement in actin cytoskeleton regulation implicates it in coordination with actin filament dynamics sharing relations with actin-binding proteins like alpha-actinin.
CTNNA2 has connections with neurological disorders such as autism and intellectual disability. Alterations in its function or expression can disrupt neural development and synaptic function leading to cognitive impairments. Additionally CTNNA2 links to other proteins implicated in these conditions such as beta-catenin which is known to affect neural development and psychiatric conditions.