Abcam, ab76867, Anti-SDPR antibody

Size: 50µg
Mouse Polyclonal SDPR antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CAVIN2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CAVIN2.O95810

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SDPR also known as serum deprivation-response protein has a molecular mass of around 43 kDa and acts mechanically by binding to phosphatidylserine within cell membranes. It plays a role in cell shape and structure due to its interaction with the cytoskeleton. This protein is expressed highly in adipocytes and several other tissues such as lung and endothelium. It localizes mainly to caveolae which are small invaginations in the plasma membrane.
Biological function summary
The serum deprivation-response protein participates in the formation and maintenance of caveolae by serving as a caveolae scaffolding component. Its interactions with other proteins support the structural integrity of cell membranes and facilitate processes like vesicular trafficking and signal transduction. SDPR contributes to caveolae-mediated signal transduction and interacts with other proteins to perform its biological functions.
Pathways
The activities of SDPR intersect with the caveolae-mediated endocytosis and actin cytoskeleton regulation. It associates with proteins such as caveolin-1 in the caveolae structure and signaling. This interaction with structural and signaling proteins enables SDPR to influence various cellular responses including the cellular reaction to stress signals and mechanical strain.
SDPR involvement connects to pulmonary arterial hypertension and multiple myeloma. Changes in its expression can affect caveolae structure and function leading to alterations in cellular mechanics and signaling pathways. In diseases like pulmonary arterial hypertension altered interactions with known proteins like caveolin-1 can exacerbate pathophysiological processes indicating the potential impact of SDPR dysregulation on vascular pathologies.