Abcam, ab76919, Anti-PTRF antibody

Size: 100µL
Rabbit Polyclonal PTRF antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CAVIN1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CAVIN1. The exact immunogen used to generate this antibody is proprietary information.Q6NZI2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTRF also known as Cavin-1 is a protein with a mass of approximately 43 kDa. It functions primarily as a regulator of caveolae formation and stability. Caveolae are small flask-shaped invaginations in the plasma membrane. PTRF interacts directly with caveolin proteins to facilitate caveolae assembly. It is largely expressed in adipose tissue muscle tissue and endothelial cells indicating a significant role in cellular processes in these cells.
Biological function summary
PTRF facilitates various processes like signal transduction and lipid metabolism due to its role in caveolae function. As part of the caveolae complex it is essential for maintaining structural integrity and organization. PTRF interacts with other proteins such as cavin family members and caveolins aiding in cellular response to mechanochemical stimuli. By regulating the caveolae PTRF influences activities including endocytosis and potocytosis.
Pathways
PTRF is critical in cholesterol homeostasis and endothelial nitric oxide synthase (eNOS) signaling pathways. It associates with caveolin-1 modulating these pathways to balance lipid composition and promote endothelial function. The interaction between PTRF and caveolin-1 enhances nitric oxide production which is important for vascular tone regulation and cellular stress response. This positions PTRF as a regulator in cardiovascular and metabolic pathways.
Defects or deficiencies in PTRF can lead to disorders such as lipodystrophy and muscular dystrophy. The absence or malfunction of PTRF disrupts normal caveolae structure leading to impaired lipid storage and muscle function. PTRF's interaction with caveolin-1 connects it to cardiovascular diseases as caveolin-1 mutations contribute to the pathogenesis of cardiac dysfunction. Understanding PTRF's role offers insights into therapeutic strategies for these conditions.