Abcam, ab77077, Anti-CCK2-R antibody

Size: 100µg
Goat Polyclonal CCK2-R antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 11 publications. Immunogen corresponding to Synthetic Peptide within Human CCKBR aa 250-300.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CCKBR aa 250-300. The exact immunogen used to generate this antibody is proprietary information.P32239

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab77077 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunising peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCK2 receptors also known as cholecystokinin B receptors play important roles in the body. These receptors are part of the G protein-coupled receptor family. They have a molecular mass of approximately 48 kDa. CCK2 receptors mainly express in the brain and gastric mucosa. In the brain they regulate neurotransmission while in the stomach they influence gastric acid secretion.
Biological function summary
CCK2 receptors interact with cholecystokinin and gastrin hormones. They are essential components of signaling complexes that mediate their effects. Interaction with these hormones leads to increased cellular calcium levels. This receptor also plays a role in modulating anxiety and pain perception in addition to its role in digestive processes.
Pathways
CCK2 receptors are key in the gastrin signaling pathway and influence the phosphoinositide pathway. These pathways involve interaction with other proteins like CCK1 receptors and tyrosine kinases. The interplay with these pathways contributes to the activation of intracellular signaling cascades that affect cell growth and digestive enzyme secretion.
CCK2 receptors have links to anxiety disorders and gastric cancers. Alterations in receptor function can influence the brain's response to stress linking it to anxiety. For gastric cancers overexpression of CCK2 receptors can lead to increased cell proliferation. Their interaction with phosphoinositide 3-kinase also plays a role in the progression of gastric cancers.