Abcam, ab79409, Anti-PARVA (phospho S8) antibody [EPR2174]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal PARVA phospho S8 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2174,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PARVA also known as α-parvin is a 42 kDa protein expressed in various tissues including muscle and endothelial cells. PARVA acts mechanically as an adaptor protein playing an important role within focal adhesions. It interacts with structural and signaling molecules integrating signals from the extracellular matrix. Through such interactions it contributes to cellular adhesion and migration processes.
Biological function summary
PARVA plays a role in cytoskeletal organization and cell shape regulation. As part of the integrin-linked kinase (ILK) complex it connects integrins at the cell surface with actin filaments in the cytoskeleton. This complex formation influences intracellular signaling pathways allowing cells to respond to mechanical stress and environmental signals. The dynamic restructuring of the actin cytoskeleton through PARVA is essential for cellular motility and morphogenesis.
Pathways
PARVA is an integral component of the PI3K-Akt signaling pathway and is also involved in the RhoA/ROCK pathway. Within these pathways it collaborates with proteins like integrin-linked kinase (ILK) and PINCH to mediate cell survival proliferation and migration. These pathways are essential for various cellular responses positioning PARVA as a significant element in controlling cellular behavior in response to external stimuli.
Research reveals PARVA's involvement in cancer progression and cardiovascular diseases. In cancer aberrant PARVA function or expression can alter cell adhesion and motility contributing to metastasis. Collaborating proteins like ILK and PINCH become deregulated influencing pathways associated with tumor growth. In cardiovascular disorders PARVA's role in endothelial cell function impacts vascular integrity where its dysregulation can lead to conditions such as atherosclerosis.