Abcam, ab80539, Anti-SCN4B antibody

Size: 100µg
Rabbit Polyclonal SCN4B antibody. Suitable for WB, ICC/IF and reacts with Human, Rat samples. Cited in 12 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCN4B also known as Sodium Channel Beta-4 Subunit is a vital component in the modulation of voltage-gated sodium channels. Its molecular mass is approximately 22 kDa. SCN4B is primarily expressed in muscle tissue and the central nervous system. It functions as an auxiliary subunit to modulate the activity and kinetics of the main alpha subunit in sodium channels therefore influencing neuronal excitability and muscle contraction.
Biological function summary
SCN4B regulates the proper functioning of sodium channels which are essential for the initiation and propagation of action potentials in neurons and muscle fibers. SCN4B does not typically form a complex on its own but works as part of the sodium channel macromolecular complex. The interaction with alpha subunits modulates the gating behavior and the cellular localization of the channel impacting how electrical signals are handled in excitable cells.
Pathways
The sodium channels influenced by SCN4B are integral to the action potential pathway and the muscle contraction pathway. SCN4B's interaction with alpha subunits like SCN4A influences signal transmission efficiency and precision. The proteins SCN5A and SCN1A are also part of these sodium channel pathways playing similar roles in different tissues such as cardiac and nervous systems.
SCN4B has connections to conditions such as periodic paralysis and epilepsy. Mutations or dysregulation of SCN4B can alter neuronal excitability contributing to pathophysiological conditions. The protein links to SCN4A in conditions involving muscle function and SCN1A in neuronal-related disorders demonstrating its role in maintaining normal electrical activity and stability across tissues.