Abcam, ab80597, Anti-USP3 antibody

Size: 100µg
Rabbit Polyclonal USP3 antibody. Suitable for IHC-P, IP and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human USP3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human USP3. The exact immunogen used to generate this antibody is proprietary information.Q9Y6I4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
USP3 also known as Ubiquitin Specific Peptidase 3 is an enzyme that functions as a deubiquitinating enzyme (DUB). This protein plays a role in removing ubiquitin moieties from polyubiquitinated protein substrates. By regulating ubiquitination USP3 controls protein degradation. The full-length human USP3 protein has a molecular mass of approximately 109 kDa. Scientists have found USP3 expression in various tissues including the liver lungs and kidneys indicating its widespread biological significance.
Biological function summary
USP3 influences the regulation of the cell cycle and genome maintenance. It does not function alone; USP3 can associate with other proteins to form complexes that modulate these intracellular processes. Its activity in deubiquitination contributes to chromatin remodeling by stabilizing or activating proteins involved in cellular division and DNA repair. Therefore USP3 plays a role in maintaining cellular integrity and preventing genomic instability.
Pathways
Deubiquitination events involving USP3 impact key regulatory circuits like the DNA damage response and cell cycle checkpoints. Within these pathways USP3 collaborates with proteins such as H2A and H2AX where it maintains their stability by deubiquitinating them. By influencing these pathways USP3 ensures the proper execution of cell cycle transitions and the DNA damage response preventing errors during replication and division.
USP3 has implications in both cancer and neurodegenerative diseases. Its dysregulation contributes to abnormal cell proliferation and defective DNA repair mechanisms which are hallmarks of various cancers including breast cancer. USP3 is also connected to Rett syndrome where it affects the stability of proteins like MECP2 involved in neuronal function. Understanding USP3's role in these diseases highlights its potential as a therapeutic target for improving treatment strategies.