Abcam, ab84327, Anti-AKR1C3 antibody

Size: 100µg
Rabbit Polyclonal AKR1C3 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Cow samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human AKR1C3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Cow,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AKR1C3. The exact immunogen used to generate this antibody is proprietary information.P42330

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The AKR1C3 protein also known as aldo-keto reductase family 1 member C3 functions as an enzyme and part of the aldo-keto reductase superfamily. AKR1C3 reduces ketosteroids and prostaglandins participating in steroid hormone metabolism. It has a molecular mass of about 37 kDa. It is expressed in various tissues such as the liver ovaries and adrenal glands.
Biological function summary
The enzyme engages in important roles in androgen estrogen and prostaglandin metabolism. AKR1C3 works in steroid biosynthesis by reducing 17-ketosteroids to their hydroxysteroid forms. It participates in the regulation of sex steroid hormones and contributes to prostaglandin metabolism though it does not function as part of a complex. Its activity can affect the balance of hormones and local cellular processes impacting a variety of biological activities.
Pathways
AKR1C3 plays significant roles in metabolic and signaling pathways including the steroid hormone biosynthesis and prostaglandin receptor pathways. It interacts with other enzymes like AKR1C2 which also works in steroid processing adding to the regulation of hormone levels and activities. These pathways enable the enzyme to alter cellular responses and influence receptor signaling.
AKR1C3 has associations with hormone-related cancers such as prostate and breast cancer. Its overexpression or misregulation could drive tumor progression by altering hormone levels that fuel cancer growth. It connects with other proteins like CYP19A1 (aromatase) involved in estrogen synthesis indicating a contribution to estrogen-sensitive cancer development. Overall AKR1C3's role in metabolic dysfunctions and hormone-related disorders emphasizes its importance as a biological target.