Abcam, ab84405, Anti-ADRA1B antibody

Size: 100µg
Rabbit Polyclonal ADRA1B antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADRA1B.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ADRA1B. The exact immunogen used to generate this antibody is proprietary information.P35368

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Purification notes-ab84405 is purified by a peptide affinity column., Storage buffer-Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADRA1B also known as alpha-1B adrenergic receptor is a G protein-coupled receptor (GPCR) involved in various cellular processes. It has a molecular mass of approximately 56 kDa. ADRA1B mainly expresses in smooth muscle cells particularly within arterial walls and cardiac tissues which suggests its involvement in cardiovascular function. It also expresses in the central nervous system reflecting a broader physiological role.
Biological function summary
Alpha-1B adrenergic receptor mediates vasoconstriction and regulates blood pressure by interacting with catecholamines like norepinephrine. This receptor participates in forming a homodimer or a heterodimer complex with other adrenergic receptors which affects its signaling capabilities and functional outcomes. The receptor's activation influences smooth muscle contraction cardiac output and alpha-adrenergic signaling.
Pathways
ADRA1B actively participates in the adrenergic signaling pathway influencing cardiovascular regulation and smooth muscle contraction. The receptor interacts with proteins such as G proteins which are central to signal transduction. It also relates to the mitogen-activated protein kinase (MAPK) pathway promoting cell proliferation and survival linking its function to both cardiac and neural activities.
ADRA1B associates with hypertension and heart failure where its overexpression or dysregulation affects vascular resistance and cardiac workload. It connects to proteins like phospholipase C which further modulate intracellular calcium levels linked to these cardiovascular conditions. Additionally changes in this receptor's function may relate to psychiatric disorders reflecting its role in the central nervous system and interactions with noradrenergic pathways.