Abcam, ab85725, Anti-MAZ antibody

Size: 100µg
Rabbit Polyclonal MAZ antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human MAZ aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human MAZ aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P56270

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MAZ protein also known as Myc-associated zinc finger protein or Pur-1 has a mass of about 49 kDa. This protein is a transcription factor and contains zinc-finger motifs that enable it to bind to specific DNA sequences influencing gene expression. MAZ is expressed in various tissues including the brain and the heart and plays a significant role in regulating various physiological processes. Researchers often study MAZ for its involvement in cellular proliferation and differentiation.
Biological function summary
MAZ influences the transcription of genes involved in cell growth and division. It does not function as part of a larger complex but acts by binding directly to DNA influencing the transcription machinery. Its activity is critical in controlling genes linked to cell cycle progression and apoptosis. Its regulatory functions help maintain normal cellular function and tissue homeostasis.
Pathways
MAZ is integral to the regulation of the MAPK and Wnt signaling pathways. The protein interacts with other signaling molecules in these pathways to modulate gene expression linked to cell proliferation and differentiation. Additionally MAZ has associations with the MYC oncogene highlighting its involvement in pathways related to cellular growth and cancer development.
Researchers find a relationship between MAZ and cancer especially glioblastoma and colorectal cancer. The protein's overexpression can contribute to oncogenic transformation and tumor progression. MAZ also connects with other proteins such as MYC in these disorders highlighting its important role in cancer-related pathways. Understanding the role of MAZ in these diseases could provide insights into therapeutic targets for limiting tumor growth.