Abcam, ab86073, Anti-ch TOG antibody

Size: 100µL
Rabbit Polyclonal ch TOG antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human CKAP5.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CKAP5. The exact immunogen used to generate this antibody is proprietary information.Q14008

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ch-TOG also known as colonic and hepatic tumor overexpressed gene serves as an important player in microtubule dynamics. With a molecular weight of approximately 217 kDa this protein is an important component in microtubule polymerization. It is expressed in various tissues including the brain and testis demonstrating its diverse role in cellular structure and division processes. As an integral part of the microtubule organizing center ch-TOG directly contributes to the assembly and stability of the mitotic spindle.
Biological function summary
Ch-TOG is highly involved in cell cycle regulation and mitosis. By interacting with microtubules it maintains the proper formation of the mitotic spindle ensuring accurate chromosome segregation in eukaryotic cells. It functions within larger protein complexes such as the Augmin complex which assists in spindle microtubule nucleation. This protein's ability to promote microtubule growth is essential for dynamic cellular events particularly during cell division.
Pathways
Ch-TOG plays a significant role in the cell cycle and mitotic spindle assembly pathways. It closely associates with proteins such as TACC3 and Aurora A kinase which regulate mitotic spindle formation and stability. In the TACC3-Aurora A pathway ch-TOG helps enhance microtubule assembly a process necessary for successful cell proliferation and division. The interaction with these critical proteins illustrates its contribution to maintaining cellular integrity during mitosis.
Ch-TOG links to cancer progression and developmental abnormalities. Its overexpression often appears in various types of cancer such as colorectal and liver cancers due to its role in promoting uncontrolled cell division. In these circumstances ch-TOG interacts with oncogenic pathways potentially involving proteins like p53 to facilitate tumor growth. Additionally mutations or dysregulation in ch-TOG can lead to improper mitotic progression contributing to developmental disorders related to cell division anomalies.