Abcam, ab86137, Anti-FBXO31 antibody

Size: 100µg
Rabbit Polyclonal FBXO31 antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human FBXO31 aa 450 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FBXO31 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5XUX0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO31 also known as F-box only protein 31 functions as part of the SCF (SKP1-Cullin-F-box) E3 ubiquitin protein ligase complex. It plays a role in marking proteins for proteasomal degradation. The molecular weight of FBXO31 is approximately 73 kDa. Gene expression analysis shows FBXO31 is present in various tissues with notable levels in the brain liver and kidney.
Biological function summary
FBXO31 regulates cell cycle progression and stress response pathways. It forms part of the SCF complex facilitating ubiquitination by recognizing and binding specific substrates. The protein contributes to the regulation of cell cycle checkpoints and is involved in DNA repair processes. This makes FBXO31 important for maintaining genomic stability during cell division and protecting against cellular stress.
Pathways
FBXO31 interacts with mechanisms like the p53 signaling pathway and the ubiquitin-dependent proteolysis pathway. In the p53 signaling pathway FBXO31 targets specific proteins that modulate p53 activity affecting cell cycle arrest and apoptosis. Additionally FBXO31 links to other proteins such as SKP1 and Cullin which are essential components of the SCF complex and participate in substrate ubiquitination.
FBXO31 has associations with cancer particularly breast and liver cancers. FBXO31 levels can influence tumor suppressor functions linking it to the pathogenesis of these cancers. Researchers have observed connections between FBXO31 and p53 mutations which further implicate its role in tumor development and progression. Understanding these associations highlights the potential of FBXO31 as a target for therapeutic strategies in oncology.