Abcam, ab86330, Anti-ZBTB40 antibody

Size: 100µg
Rabbit Polyclonal ZBTB40 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZBTB40 aa 1100-1200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZBTB40 aa 1100-1200. The exact immunogen used to generate this antibody is proprietary information.Q9NUA8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab86330 was affinity purified using an epitope specific to ZBTB40 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZBTB40 also known as Zinc Finger and BTB Domain-Containing Protein 40 functions mainly as a transcription factor involved in gene regulation. This protein has a molecular weight of approximately 87 kDa. Researchers have observed its expression in various tissues though it is found at higher levels in skeletal tissues. The presence of zinc finger domains suggests its role in DNA binding influencing the transcription of specific genes.
Biological function summary
ZBTB40 participates in bone-related functions. It is not known to be part of any complex. Scientists have associated it with osteoblast differentiation and bone formation indicating its role in skeletal development. The regulation of genes by ZBTB40 influences cellular processes that contribute to the structural and functional integrity of bone tissue.
Pathways
ZBTB40's activities align with bone morphogenetic protein (BMP) signaling and Wnt signaling pathways. These pathways are critical for bone growth and remodeling. ZBTB40 interacts with proteins involved in these pathways such as BMPs and Wnt family proteins modulating their effects downstream. These interactions help coordinate the complex signaling necessary for maintaining bone health.
ZBTB40 has links to osteoporosis and skeletal dysplasia. Researchers have studied its regulatory functions in bone mineral density connecting it to conditions of bone fragility and poor bone development. The protein also interacts with RUNX2 an important factor involved in skeletal system health exacerbating or mitigating disease progression based on ZBTB40's activity levels. Understanding these connections provides insights into potential therapeutic targets for these bone-related conditions.