Abcam, ab86383, Anti-p53 BP3 antibody

Size: 100µL
Rabbit Polyclonal p53 BP3 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TOPORS aa 950 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TOPORS aa 950 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9NS56

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P53 BP3 also known as BCCIP (BRCA2 and CDKN1A interacting protein) weighs approximately 36 kilodaltons. Researchers find it mainly expressed in actively dividing cells within tissues like testis ovary and several cancer cell lines indicating its potential significance in cell cycle regulation and maintenance. p53 BP3 interacts with other components of the cellular machinery to fulfill its roles and it has garnered interest due to its association with p53 a well-known tumor suppressor protein.
Biological function summary
Alongside being associated with cell cycle checkpoints p53 BP3 participates in DNA damage response and repair processes. It works in close association with proteins like BRCA2 and p21 potentially forming part of a complex that ensures genomic stability and assists in cell cycle arrest in response to DNA damage. Through these interactions p53 BP3 contributes to the effective management and repair of DNA lesions supporting the orderly progression through the cell cycle.
Pathways
Cell cycle and DNA damage response pathways both involve p53 BP3. In the p53 signaling pathway it interacts with p53 which coordinates cell cycle arrest and DNA repair. In the DNA damage response pathway BRCA2 and p21 are closely linked to p53 BP3 facilitating homologous recombination and checkpoint control. p53 BP3’s role here ensures proper cellular responses to prevent mutations from being passed on during cell division.
P53 BP3 has been implicated in various cancers as its dysfunction can lead to aberrant cell cycle control and insufficient DNA repair. This link emphasizes its relationship with proteins like BRCA2 often seen with breast cancer predisposition. Additionally decreased levels or mutations of p53 BP3 have connections to neurodegenerative disorders where cellular stress and compromised DNA repair mechanisms contribute to disease progression.