Abcam, ab86613, Anti-CEP76 antibody

Size: 100µg
Rabbit Polyclonal CEP76 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CEP76 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CEP76 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q8TAP6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CEP76 also known as Centrosomal protein 76 plays a role in the regulation of centriole duplication. It has an approximate molecular mass of 76 kDa. The protein is mainly expressed in the centrosome of eukaryotic cells. Centrosomes are important because they serve as the main microtubule-organizing centers which is important for cell division. CEP76 is also expressed in diverse human tissues and is critical in controlling the number of centrioles in dividing cells.
Biological function summary
CEP76 limits centriole duplication ensuring cells do not produce an excess number. It operates independently and is not a component of any larger protein complex known. But it interacts with other centrosomal proteins like CEP152 for its function. This interaction is important to maintain proper centriole numbers and is essential for genome stability during cell replication.
Pathways
CEP76 is involved in the p53 signaling pathway that controls cell cycle checkpoints and apoptosis. The activity of CEP76 ensures only one centriole cycle per cell cycle which aligns with the actions of related proteins like PLK4 a known regulator of centriole biogenesis. Correct functioning of this pathway is important for cell cycle regulation and preventing uncontrolled cell proliferation.
Abnormalities in CEP76 expression or function are connected to microcephaly and cancer. Microcephaly a condition where a person has a smaller head size due to improper cell division during brain development can result from disrupted centriole duplication. In cancer misregulation of centrosome numbers leads to genetic instability driving tumor progress. CEP76's interaction with proteins like CEP152 and PLK4 further affects tumor biology as centriole amplification often leads to chromosomal instability seen in cancerous cells.