Abcam, ab86783, Anti-DLG5 antibody

Size: 100µg
Rabbit Polyclonal DLG5 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human DLG5 aa 1300-1400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human DLG5 aa 1300-1400. The exact immunogen used to generate this antibody is proprietary information.Q8TDM6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab86783 was affinity purified using an epitope specific to DLG5 immobilized on solid support., Storage buffer-pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein Discs Large MAGUK Scaffold Protein 5 known as DLG5 functions as a scaffolding protein. It is part of the membrane-associated guanylate kinase (MAGUK) family and has an approximate mass of 220 kDa. DLG5 contains multiple domains including PDZ SH3 and GK which assist in protein-protein interactions. This protein is expressed in various tissues including the heart brain and skeletal muscle implying its widespread importance in different physiological contexts.
Biological function summary
The DLG5 protein plays a role in cell polarity and tissue development. It associates with components of the cytoskeleton and participates in maintaining the structural integrity of cells. DLG5 is part of a larger protein complex that regulates the signaling pathways important for cell differentiation and proliferation. Its interactions are essential for establishing cellular junctions that uphold cell adhesion and tissue architecture.
Pathways
The DLG5 protein is an integral part of the Hippo and Wnt signaling pathways. These pathways are critical in regulating cell growth and apoptosis. In the Wnt pathway DLG5 interacts with other proteins such as beta-catenin to influence gene transcription that steers cell cycle progression. In the Hippo pathway DLG5 interfaces with the LATS1/2 kinases to maintain control over organ size by modulating cell proliferation and apoptosis.
The DLG5 protein shows a connection to inflammatory bowel disease and some cancers. Mutations or altered expression of DLG5 have been linked to Crohn's disease suggesting its role in intestinal barrier function. Additionally its involvement in cancer highlights a relationship with tumor suppressor pathways. Through these diseases the protein interacts with others like APC and TCF within pathways that change cell adhesion and proliferation potentially assisting tumor development or impacting inflammatory responses.