Abcam, ab88370, Anti-RAD51AP1 antibody

Size: 50µg
Mouse Polyclonal RAD51AP1 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RAD51AP1.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RAD51AP1.Q96B01

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RAD51 associated protein 1 also called RAD51AP1 is a protein with a molecular mass of approximately 41 kDa. It interacts directly with RAD51 to assist in DNA repair processes. RAD51AP1 is present in a variety of tissues with higher expression levels seen in testes and ovaries. This protein localizes in the nucleus where it takes part in processes involving DNA repair and stability.
Biological function summary
RAD51AP1 plays an important role in homologous recombination a critical process for the repair of double-strand breaks in DNA. It forms a complex with RAD51 to facilitate the homologous pairing and strand exchange steps of recombination. This interaction helps stabilize the RAD51 nucleoprotein filament which is important for successful recombination events. Apart from RAD51 it also interacts with other proteins involved in DNA repair pathways highlighting its collaborative function in maintaining genomic integrity.
Pathways
RAD51AP1 operates within the DNA damage repair pathway specifically in the homologous recombination repair mechanism. This pathway ensures that DNA double-strand breaks are accurately repaired preventing genomic aberrations. In this pathway the protein works in coordination with RAD51 and other recombinase proteins to facilitate error-free repair. RAD51AP1 also displays a connection to BRCA1 pathways; BRCA1 is another critical player in DNA repair and maintaining genomic stability.
RAD51AP1 has implications in cancer particularly breast and ovarian cancers. Mutations or dysregulation of RAD51AP1 may compromise the DNA repair mechanism leading to increased genomic instability and cancer susceptibility. Furthermore it relates to BRCA1 since both are involved in DNA repair pathways and mutations in BRCA1 are known to significantly elevate cancer risks. Understanding RAD51AP1 interactions and functions offers potential insights into targeted cancer therapies.