Abcam, ab88695, Anti-IPO5 antibody

Size: 50µg
Mouse Polyclonal IPO5 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IPO5.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IPO5.O00410

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target IPO5 also known as Importin-5 functions mechanically as a nuclear transport receptor. Importin-5 has a molecular mass of approximately 120 kDa. It operates within the importin-beta family and facilitates protein transport across the nuclear envelope by recognizing nuclear localization signals. IPO5 expresses in a variety of tissues with higher levels noted in areas such as the brain and testis.
Biological function summary
Understanding its role in cargo transport into the nucleus helps researchers comprehend cellular function and regulation. IPO5 forms part of a complex responsible for binding and importing nucleoplasmin-class cargoes establishing its significance in relaying proteins imperative for cell cycle progression and genome regulation. By shuttling these cargo proteins IPO5 maintains nuclear pore complex functionality and contributes to cellular dynamics.
Pathways
IPO5 serves an integral role in nucleocytoplasmic transport and the cell cycle. It exhibits interaction with the Ran GTPase pathway essential for the import and export cycle of proteins between the cytoplasm and nucleus. IPO5's activity is related to other importin-beta family proteins which are important for transporting proteins involved in transcription and other nuclear processes.
IPO5 shows connections to certain cancer forms and neurodegenerative diseases. Deregulation of IPO5 can influence tumorigenesis due to its involvement in controlling cell proliferation. Its association with proteins like TP53 indicates its relevance in tumor suppression pathways. Additionally alterations in IPO5 functionality have implications in neurodegeneration affecting proteins important for neuronal health and survival.