Abcam, ab88862, Anti-ZNF468 antibody

Size: 50µg
Mouse Polyclonal ZNF468 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF468.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ZNF468.Q5VIY5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF468 also known as Zinc Finger Protein 468 functions as a transcription factor. Its molecular mass is approximately 69 kDa. It contains multiple zinc finger motifs that bind to DNA regulating gene expression. This protein is expressed in nuclear compartments and detected in various tissues but shows high levels in brain and testis. This localization suggests that ZNF468 plays an essential role in processes involving DNA interaction and regulation.
Biological function summary
Transcription factors like ZNF468 influence cellular differentiation and development by activating or repressing specific genes. ZNF468 does not seem to be a part of a major protein complex but can cooperate with other transcription factors to modulate gene expression profiles. By directly binding to DNA sequences it executes its role in directing transcriptional regulation which can impact cellular growth and response mechanisms.
Pathways
Zinc finger proteins such as ZNF468 play critical roles in the regulation of the Wnt signaling pathway and the apoptosis pathway. Through its regulatory functions ZNF468 affects the expression of genes involved in these pathways. It influences cellular proliferation and survival processes working in a network with other proteins like beta-catenin and c-Myc which are recognized components of these pathways. This involvement highlights the importance of maintaining proper ZNF468 function for cellular equilibrium.
Aberrations in ZNF468 expression or function relate to issues in neuromuscular diseases and certain cancers where regulation of cell growth is disrupted. For example in oncogenesis its interaction with other transcription factors might influence the expression of oncogenes such as p53. Neuromuscular disorders may arise from its role in neuronal development and maintenance as imbalances in gene expression can lead to degeneration. Consequently any mutation or dysregulation of ZNF468 can potentially impact cellular pathways and lead to disease progression.