Abcam, ab89334, Anti-Factor X + Xa antibody [MM0192-10A10]

Size: 50µg
Mouse Monoclonal Factor X antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human F10.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:MM0192-10A10,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human F10.P00742,
Specificity:ab89334 detects Factor X and Xa.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution., Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Factor X also known as Stuart-Prower factor and its active form Factor Xa play key roles in the blood coagulation cascade. Factor X is a serine protease with a molecular mass of approximately 59 kDa. It is synthesized in the liver and circulates in the plasma as an inactive precursor. Upon activation to Factor Xa it catalyzes the conversion of prothrombin to thrombin an important step in the clotting process that leads to the formation of a blood clot.
Biological function summary
Factor X and its active form Xa play a central role in coagulation. They are part of a complex known as the prothrombinase complex which includes Factor V calcium ions and phospholipids. This complex rapidly enhances the conversion of prothrombin to thrombin which then facilitates the conversion of fibrinogen to fibrin forming a stable fibrin clot. Factor Xa is tightly regulated by inhibitors such as antithrombin to ensure balanced coagulation.
Pathways
Factor X and Xa are integral to the intrinsic and extrinsic pathways of coagulation which converge at the activation of Factor X. In the intrinsic pathway the activation involves interactions with other factors such as Factor IX and VIII. Meanwhile in the extrinsic pathway tissue factor (Factor III) and Factor VIIa initiate the cascade leading to Factor X activation. These pathways illustrate the interconnectedness and regulatory mechanisms involved in hemostasis.
Factor X and Xa have significant implications. Deficiencies or dysfunctions in Factor X can lead to a rare bleeding disorder known as Factor X deficiency characterized by symptoms such as nosebleeds and gastrointestinal bleeding. Conversely excessive activity or inadequate regulation of these factors is linked to thrombotic conditions such as deep vein thrombosis. In such cases proteins like antithrombin and tissue factor pathway inhibitor become critical in managing the increased coagulation risk.