Abcam, ab89526, Anti-DHX29 antibody

Size: 50µg
Mouse Polyclonal DHX29 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DHX29.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human DHX29.Q7Z478

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DHX29 also known as ATP-dependent helicase DHX29 is a member of the DExH/D-box helicase family. It has an approximate molecular mass of 138 kDa. This protein acts as a helicase which unwinds RNA structures a critical step during translation initiation. DHX29 can be found in the cytoplasm of various human cells where it plays a part in cellular protein synthesis machinery. Its expression appears in diverse tissue types underlining its role in maintaining cellular function.
Biological function summary
DHX29 regulates efficient translation initiation by interacting with the ribosomal 40S subunit. It is critical for resolving the secondary structures within the 5' untranslated regions (UTRs) of mRNAs enabling ribosomes to properly locate the start codon. DHX29 does not necessarily form part of a larger complex but it directly interacts with the translation machinery including several initiation factors that modulate protein synthesis.
Pathways
The activity of DHX29 links to the mTOR signaling pathway which regulates cell growth and metabolism in response to nutrient signals. Additionally DHX29 associates with the integrated stress response controlled by the protein kinase GCN2. In these pathways DHX29 contributes to maintaining translation under varying cellular conditions ensuring that cells can adapt to different metabolic and stress-related signals.
Alterations in DHX29 expression or function have potential links to cancerous conditions where dysregulated protein synthesis often contributes to oncogenesis. Abnormal DHX29 activity might also relate to neurological disorders due to its role in neuronal protein synthesis. In cancer DHX29's connection to mTOR pathway components such as S6K1 and 4EBP1 makes it relevant to understanding tumorigenesis and possible therapeutic avenues.