Abcam, ab89985, Recombinant human Rab-6 protein

Size: 50µg
Recombinant human Rab-6 protein is a Human Full Length protein, in the 1 to 208 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Activity: 100 pmol of protein can bind > 80 pmol of GDP.,
Accession:P20340,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.2Constituents: 0.952% HEPES, 0.475% Magnesium chloride, 0.29% Sodium chloride, 0.0462% 1,4-Dithioerythritol, 0.00044% GDP

Product details:
Protein previously labeled as RAB6A.

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Rab-6 also known as Ras-related protein 6 acts as a GTPase involved in membrane trafficking. This protein has a molecular mass of approximately 24 kDa. Researchers find Rab-6 expressed in various tissues with high levels in the brain and lungs. It localizes primarily to the Golgi apparatus where it participates in the regulation of intracellular transport.
Biological function summary
Rab-6 aids in the coordination of retrograde vesicle transport from the Golgi to the endoplasmic reticulum. Rab-6 functions as part of a complex with other proteins including dynactin and cytoplasmic dynein to facilitate these movements. Its role includes ensuring proper delivery and sorting of proteins within the cell which is essential for maintaining cellular organization and function.
Pathways
This protein is involved in the endocytosis and secretory pathways. In the endocytosis pathway Rab-6 interacts with proteins like Rab GDI and Rab escort protein to regulate vesicle transport. In the secretory pathway the protein ensures that cargo proteins transit correctly through the Golgi interacting with other Rab family members such as Rab-1 which also play parts in vesicle movement and secretion processes.
Rab-6 has been implicated in neurological disorders and certain cancers. For instance abnormalities in Rab-6 function have been linked to Alzheimer's disease where it associates with proteins like amyloid precursor protein affecting its processing. Additionally altered Rab-6 activity can contribute to cancer metastasis through interactions with metastasis-related proteins which influences cell migration and invasion mechanisms.