Abcam, ab90573, Anti-LIP1 antibody

Size: 100µg
Rabbit Polyclonal LIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human STK11IP aa 900-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human STK11IP aa 900-950. The exact immunogen used to generate this antibody is proprietary information.Q8N1F8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIP1 also known as Lipone is a mechanistic protein involved in cellular lipid metabolism. It has an approximate molecular mass of 60 kDa and is highly expressed in liver and adipose tissues in humans. Its role includes acting as an enzyme responsible for catalyzing the breakdown of lipids within cells. By participating in these processes LIP1 facilitates the regulation of lipid homeostasis impacting the availability of fatty acids and glycerol for cellular energy needs.
Biological function summary
LIP1 plays an important role in the cellular lipid degradation process. It functions as part of a multiprotein complex that includes lipid transporters and other metabolic enzymes. This involvement allows the protein to manage lipid turnover and maintain balance within cellular environments. Within cells LIP1 modulates lipid storage and release adapting these processes in response to cellular energy status and nutrient availability.
Pathways
LIP1 contributes significantly to the fatty acid oxidation and lipolysis pathways. In these pathways LIP1 interacts with proteins such as hormone-sensitive lipase and adipose triglyceride lipase aiding in the effective breakdown and utilization of stored triglycerides. These pathways not only contribute to cellular energy production but also influence metabolic rate and energy expenditure at the organism level.
LIP1 is connected to metabolic conditions such as obesity and type 2 diabetes. Its dysfunction can lead to impaired lipid metabolism and excessive lipid accumulation contributing to these metabolic disorders. Additionally LIP1 has been studied in relation to its interactions with proteins like peroxisome proliferator-activated receptor gamma which plays roles both in lipid metabolism and in the pathophysiology of these conditions. Understanding LIP1's activities offers potential therapeutic targets for metabolic diseases treatment.