Abcam, ab90630, Anti-Sodium/Hydrogen Exchanger 3/NHE-3 antibody

Size: 100µL
Rabbit Polyclonal Sodium/Hydrogen Exchanger 3/NHE-3 antibody. Suitable for WB, IHC-Fr and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Sodium/Hydrogen Exchanger 3 (NHE-3) also known as the Na/H Exchanger is an important protein responsible for sodium ion transport across cell membranes mainly in exchange for protons (H+ ions). Its molecular mass is approximately 85 kDa. NHE-3 is extensively expressed in epithelial cells particularly in the renal proximal tubules and the small intestine where it plays an essential role in fluid and electrolyte balance.
Biological function summary
The NHE-3 transporter facilitates the reabsorption of sodium ions contributing to cellular pH regulation and volume control. It operates as part of a larger multiprotein complex involving various regulatory proteins that fine-tune its activity. The exchanger activity is critical for maintaining homeostasis and proper cellular function influencing processes like nutrient absorption and acid-base balance in different tissues.
Pathways
The NHE-3 transporter plays significant roles in fluid reabsorption and bicarbonate reabsorption pathways. It functions in concert with other transporters and channels such as the Na-K ATPase pump which is key to maintaining sodium and potassium gradients. These pathways highlight the exchanger's contributions to renal and digestive systems emphasizing its interaction with proteins such as carbonic anhydrase within these processes.
Issues with NHE-3 function link to hypertension and chronic kidney disease. Malfunction or dysregulation of this Na/H exchanger can disrupt sodium balance and blood pressure regulation leading to these conditions. Changes in NHE-3 activity also connect to pathologies involving other proteins like Angiotensin II which can influence its expression and activity within the renal system further impacting disease progression.