Abcam, ab91451, Anti-ABCC10 antibody [M7I-3]

Size: 500µL
Rat Monoclonal ABCC10 antibody. Suitable for ICC and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC10 aa 150-300.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:M7I-3,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ABCC10 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q5T3U5

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.3Preservative: 0.1% Sodium azideConstituents: 0.7% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ABCC10 protein also known as Multidrug Resistance Protein 7 (MRP7) functions as an ATP-binding cassette transporter. It contributes to multidrug resistance by extruding a variety of xenobiotics and physiological substrates out of cells. The ABCC10 protein has a mass of about 171 kDa. Researchers have found ABCC10 expression in various tissues including the liver lung and testis suggesting its diverse role in different cell types.
Biological function summary
This transporter plays critical roles in cellular detoxification processes. ABCC10 is part of the larger ATP-binding cassette (ABC) transporter family which includes other transporters like ABCC1 and ABCC2. By actively transporting drugs and organic anions across cellular membranes ABCC10 helps regulate the intracellular concentrations of these compounds and maintain cellular homeostasis.
Pathways
ABCC10 participates in the detoxification and xenobiotic metabolism pathways interacting with enzymes such as cytochrome P450s. The protein contributes to the resistance against various chemotherapy drugs by exporting them out of cells impacting the drug metabolism pathway. This function is related to other ABC transporters like ABCC1 which similarly influence drug clearance and pharmacokinetics.
ABCC10 has been implicated in cancer chemotherapy resistance. Many studies have noted that overexpression of ABCC10 correlates with reduced drug accumulation in cancer cells resulting in chemotherapy failure. Its function is also connected to the protein P-glycoprotein another drug transporter that plays a similar role in multidrug resistance highlighting the complex network of transporters involved in therapeutic resistance.