Abcam, ab91453, Anti-ABCC12 antibody [M9I-38]

Size: 500µL
Rat Monoclonal ABCC12 antibody. Suitable for ICC, WB, IHC-Fr and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCC12 aa 1-50.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:M9I-38,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-Fr, WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ABCC12 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q96J65

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.3Preservative: 0.1% Sodium azideConstituents: 0.7% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ABCC12 also known as ATP-binding cassette sub-family C member 12 is a protein that functions as a transporter. It belongs to the superfamily of ABC (ATP-binding cassette) transporters. The protein is encoded by the ABCC12 gene and has a molecular mass of approximately 174 kDa. ABCC12 expresses itself in various tissues including the brain testis and other cellular locations. Its expression patterns suggest a role in mediating the movement of molecules across cellular membranes though the complete spectrum of substrates for ABCC12 remains under investigation.
Biological function summary
ABCC12 works as a transporter moving endogenous and xenobiotic substances across biological membranes. It is not part of a well-characterized complex but it shares functional similarities with other members of the ABC transporter family. These proteins contribute to the cellular processes such as detoxification and the maintenance of cellular homeostasis. Researchers have noticed that alterations in ABCC12 expression can have impacts on cellular resistance to certain drugs suggesting a protective role in different cell types.
Pathways
ABCC12 is involved in the processes related to the movement of lipophilic anions and peptides. It is connected with the ABC transporter pathway which is critical in the metabolism and transport of molecules in and out of cells. ABCC12 interacts with proteins related to the multi-drug resistance pathway such as other ABC family members like ABCC1. These pathways highlight its involvement in cellular defense mechanisms against environmental toxins and metabolic waste products.
Mutations or malfunctions in ABCC12 have been linked to specific health conditions although direct links are still being explored. Studies suggest potential involvement in certain cancer types due to its role in drug resistance making it a potential target for therapeutic intervention. Furthermore it may have implications in neurological disorders given its expression in brain tissue and its related proteins in the ABC family such as ABCC8 which have established roles in insulin secretion and neuronal activity. Continued research seeks to clarify the specific contribution of ABCC12 in these contexts.