Abcam, ab91476, Anti-RIP140 antibody

Size: 200µL
Goat Polyclonal RIP140 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Nuclear receptor-interacting protein 1 aa 1050-1100.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Nuclear receptor-interacting protein 1 aa 1050-1100. The exact immunogen used to generate this antibody is proprietary information.P48552

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab91476 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RIP140 also known as receptor-interacting protein 140 and NRIP1 is a protein that acts as a transcriptional corepressor. It has a molecular mass of approximately 115 kDa. RIP140 is found in various tissues with high levels of expression observed in the ovary testes and adipose tissue. This protein interacts with nuclear receptors and influences gene expression by recruiting chromatin-modifying enzymes.
Biological function summary
RIP140 functions in regulating energy homeostasis and reproductive processes. It plays an important role in the repression of genes involved in metabolism and fat storage. RIP140 does not act alone but is part of transcriptional complexes that modulate the activity of multiple facets of gene expression. Its ability to interact with histone deacetylases and other corepressors enhances its regulatory capacity.
Pathways
RIP140 is involved in pathways that govern glucose and lipid metabolism. It interacts notably with PPAR (peroxisome proliferator-activated receptors) and LXR (liver X receptors) both important in lipid metabolism. Energy balance influences genes that RIP140 represses or activates positioning it as a central player in metabolic regulation.
RIP140's role becomes apparent in obesity and type 2 diabetes. Abnormal expression or function of RIP140 affects metabolic pathways contributing to these conditions. The protein also interacts with PGC-1α an important regulator of mitochondrial biogenesis linking it to metabolic health and disease states. Such interactions highlight the protein's significance in maintaining normal physiological balance and its potential as a therapeutic target.