Abcam, ab92967, Recombinant Human PDCD2 protein

Size: 10µg
Recombinant Human PDCD2 protein is a Human Full Length protein, in the 1 to 344 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:Tag free,
Applications:SDS-PAGE, WB, Mass Spec, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16342,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.4Constituents: PBS

Properties and Storage Information:
Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The programmed cell death protein 2 (PDCD2) plays a significant role in apoptosis also known as programmed cell death. It has alternate names such as RP8 and it is composed of approximately 38 kDa. PDCD2 expression occurs widely across various tissues which indicates a basic function in cellular processes. The protein is typically localized within the nucleus and holds a zinc finger motif that suggests its ability to interact with nucleic acids impacting gene transcription and apoptosis mechanisms.
Biological function summary
PDCD2 influences cell proliferation and apoptosis which makes it an important factor in maintaining cellular homeostasis. Researchers have identified PDCD2 as a part of the nucleosome assembly that contributes to chromatin organization. This assembly implicates PDCD2 in DNA replication and transcription regulation. By influencing these processes PDCD2 supports normal cell cycle progression affirming its importance in cellular growth and division.
Pathways
Programmed cell death and cell cycle pathways are among the significant processes involving PDCD2. It interacts with the p53 pathway an important regulator of the cell cycle and apoptosis. This interaction highlights the importance of PDCD2 in genomic stability and stress responses. PDCD2 also associates with BCL-2 family proteins which further integrates its function with apoptotic and survival pathways showcasing its role in controlling cell fate.
PDCD2 has a connection to cancer and autoimmune diseases. Its dysregulation can lead to uncontrolled cell growth frequently observed in malignancies such as leukemia. PDCD2 downregulation is associated with an increase in tumorigenic behaviors relating to its interaction with proteins like p53 that are often mutated or dysfunctional in cancers. In autoimmune disorders PDCD2 implications suggest its role in abnormal immune cell apoptosis leading to prolonged immune cell survival which contributes to pathological autoimmunity.