Abcam, ab93606, Anti-CACNB2 antibody [N8B/1]

Size: 100µg
Mouse Monoclonal CACB2 antibody. Suitable for IHC-P, IP, Flow Cyt, WB, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 3 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N8B/1,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-Fr, ICC/IF, IHC-P, WB, Flow Cyt, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:No cross reactivity against CAVB1, CAVB3 and CAVB4

Product details:
The clone number has been updated from S8b-1 to N8B/1, both clone numbers name the same antibody clone.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CACNB2 also known as the calcium channel voltage-dependent beta 2 subunit is a part of the high voltage-gated calcium channel complex. The protein encoded by CACNB2 gene has a mass of approximately 66 kDa. It exists within many tissues including cardiac tissue skeletal muscle and the brain. This protein plays a role in modulating the activity of the channel by interacting with both alpha and gamma subunits influencing calcium ion influx.
Biological function summary
CACNB2 participates in controlling calcium channel activity which is significant for various cellular processes. It forms a part of the channel complex that helps stabilize the arrangement and activity of the pore-forming alpha subunit. Through this CACNB2 affects processes such as muscle contraction neurotransmitter release and gene expression. Interactions of CACNB2 subunits help regulate the amplitude and kinetics of calcium currents important for cellular communication.
Pathways
CACNB2 regulates the L-type calcium channel pathway integral to the excitation-contraction coupling in cardiac and muscle cells. It associates with other calcium channel subunits like CACNA1C modulating calcium channel functionality. In the MAPK signaling pathway CACNB2 indirectly influences cellular responses to various stimuli. This protein provides essential inputs to these pathways by affecting calcium ion flow into cells which is critical for their activation and operation.
CACNB2 exhibits a connection to conditions such as cardiac arrhythmias and epilepsy. Its role in calcium channel functioning relates to arrhythmogenic activities in cardiac cells when abnormalities in ion flow occur. There is also evidence linking CACNB2 to epilepsy where disrupted calcium flow affects neuronal firing patterns. Other related proteins like CACNA1C also play a part in these disorders highlighting the complex interactions between voltage-gated calcium channel components in disease mechanisms.