Abcam, ab94965, Anti-Respiratory Syncytial Virus Phosphoprotein antibody [RSVH102]

Size: 50µg
Mouse Monoclonal PHOSP antibody. Suitable for IP, ELISA, WB, ICC/IF, IHC-Fr and reacts with Respiratory syncytial virus samples. Cited in 12 publications. Immunogen corresponding to Cell preparation containing Respiratory Syncytial Virus Phosphoprotein protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:RSVH102,
Isotype:IgG1,
Carrier free:No,
Reacts with:Respiratory syncytial virus,
Applications:ELISA, IHC-Fr, WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab94965 has broad specificity for Human Respiratory Syncytial Virus of both sub-groups A and B.

Product details:
Fusion partner: PS-NS/1-Ag4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Respiratory Syncytial Virus (RSV) Phosphoprotein also known as P or M2-1 protein acts mechanically as an important component of the virus's RNA synthesis machinery. It is a nonstructural protein with a molecular mass of approximately 27 kDa. The phosphoprotein is expressed abundantly in infected host cells during RSV replication. Functionally its primary role involves forming a complex with the RSV nucleoprotein and the large polymerase protein which are essential for viral RNA transcription and replication.
Biological function summary
The RSV Phosphoprotein plays a significant role in stabilizing the RNA polymerase complex during viral gene expression. This protein does not act alone; it is part of a larger ribonucleoprotein complex that ensures efficient transcription of viral mRNA. It facilitates the assembly of enzyme components on the viral genome promoting fidelity in the transcription and replication processes which is important for the virus's infectivity.
Pathways
The RSV Phosphoprotein is deeply involved in the viral assembly and replication pathway. It interacts primarily with the nucleoprotein (N) and the polymerase protein (L) forming an active transcription complex. This protein coordinates processes within the viral life cycle such as replication and viral assembly directly impacting protein interactions that guide the synthesis of new viral particles within the RSV replication pathway.
RSV Phosphoprotein is linked to respiratory tract infections like bronchiolitis and pneumonia. Its interaction with nucleoprotein and polymerase protein not only contributes to the virus's ability to propagate but also helps evade host immune responses making it a target for antiviral interventions. Understanding this protein's interactions with other RSV-specific proteins opens possibilities for therapeutic development targeting respiratory diseases.