Abcam, ab955, Anti-CD68 antibody [KP1]

Size: 100µg / 1mg
Anti-CD68 antibody [KP1] (ab955) is a mouse monoclonal antibody detecting CD68 in Western Blot, IHC-P, ICC/IF . Suitable for Human . - Over 620 publications - Trusted since 2002
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:KP1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Anti-CD68 antibody [KP1] (ab955) is a mouse recombinant monoclonal antibody and is validated for use in ICC/IF, IHC-P and WB.
Anti-CD68 antibody [KP1] (ab955) was first used in a scientific publication in 1989 and has been cited over 620 times in peer reviewed journals. It's performance in IHC and Immunofluorescence in human and mouse samples is trusted by the scientific community.
Abcam's high quality manufacturing and validation processes ensure Anti-CD68 antibody [KP1] (ab955) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Anti-CD68 antibody [KP1] (ab955) has 44 independent reviews from customers.
Anti-CD68 antibody [KP1] (ab955) specifically detects CD68 (UniProt ID: P34810; Molecular weight: 36kDa) and is sold in a convenient trial size to enable initial testing (10ug ) and larger sizes for subsequent scaling up experiments (100 ug and 1 mg).
Conjugation-ready, carrier free format available for antibody clone KP1 -
ab233172
Antibody clone KP1 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor
488, Alexa Fluor
555, Alexa Fluor
594, Alexa Fluor
647, Biotin (
ab222914
ab279323
ab282650
ab314474
ab317601
CD68 levels is implicated in autoimmune conditions like rheumatoid arthritis, where macrophages contribute to joint inflammation and damage. Specificity and sensitivity confirmed in IHC with multi-tissue microarray (TMA) validation
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD68 also known as KP1 or ED1 is a glycoprotein mainly expressed on the surface of macrophages and monocytes. Structurally it is a member of the lysosome-associated membrane protein (LAMP) family and has a molecular weight of approximately 110 kDa. This protein is often used as a marker in immunohistochemistry (IHC) and immunofluorescence staining to identify macrophages in various tissues. Researchers rely on anti-CD68 antibodies for Western blot and other analytical techniques to study its expression and function.
Biological function summary
CD68 participates in the innate immune response by allowing macrophages to bind internalize and process various antigens. This protein does not function as part of a larger complex but plays a role in processes such as phagocytosis and cytokine release. Its involvement in antigen presentation suggests a role in both initiating and regulating immune cell responses. Through these mechanisms CD68 supports the clearance of pathogens and debris from the body’s tissues.
Pathways
Researchers have highlighted that CD68 plays a significant part in the inflammatory response and atherogenesis. In these pathways CD68 interacts with C1q and other scavenger receptors on macrophages to mediate lipid uptake and foam cell formation. The protein is also connected to the regulation of cytokines like IL-1 and IL-6 which are critical in inflammatory signaling pathways promoting further immune responses.
Studies indicate that CD68 expression is prominent in atherosclerosis and certain types of cancer such as lymphoma. In atherosclerosis CD68-expressing macrophages accumulate lipids leading to foam cell formation and plaque development. Moreover in cancerous conditions CD68 often correlates with tumor-associated macrophages (TAMs) playing a role in tumor progression and immune evasion. In these disorders CD68 frequently interacts with proteins involved in chronic inflammation offering potential targets for therapeutic interventions.