Abcam, ab9566, Anti-Aquaporin 1 antibody [1/22]

Size: 100µg
Anti-Aquaporin 1 antibody [1/22] (ab9566) is a mouse monoclonal antibody detecting Aquaporin 1 in Western Blot, Flow Cytometry, IHC-P . Suitable for Human, Rat . - Over 60 publications - Trusted since 2002
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1/22,
Isotype:IgG2b,
Light chain type:kappa,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AQP1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P29972,
Epitope:Intracellular C-terminal AQP 1 epitope (active channel loop)

Product details:
What is this antibody validated in?
Anti-Aquaporin 1 antibody [1/22] (ab9566) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P) in Human, Rat samples.
What is the molecular weight of Aquaporin 1?
Anti-Aquaporin 1 [1/22] (ab9566) specifically detects a band for Aquaporin 1 (UniProt: P29972) at a molecular weight of 29kDa.
Trusted by the scientific community
Anti-Aquaporin 1 [1/22] (ab9566) was first used in a scientific publication in 2002 and has been cited over 60 times in peer-reviewed journals.
Reviewed by scientists
Anti-Aquaporin 1 [1/22] (ab9566) has over 15 independent reviews from customers.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.097% Sodium azideConstituents: PBS, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Aquaporin 1 also known as Aquaporin-1 AQP-1 or AQP1 is a protein that functions as a water channel facilitating the transport of water across cell membranes. This protein plays an important role in maintaining water homeostasis within cells. Aquaporin 1 has a mass of approximately 28 kDa and is encoded by the AQP1 gene. It is expressed in various tissues and organs including the kidneys lungs and red blood cells indicating its importance in diverse physiological processes.
Biological function summary
Aquaporin 1 is not part of a complex but independently contributes to maintaining osmotic balance and fluid movement across epithelial and endothelial tissues. The protein's selective permeability for water without allowing ions or other solutes highlights its specificity in controlling water transport which is essential for maintaining cellular environment stability.
Pathways
The aquaporin protein is involved in key biological pathways such as the osmoregulatory pathway and the fluid secretion pathway. It maintains efficient water transport in processes like urine concentration in the kidneys and fluid regulation in the pulmonary system. Aquaporins in general are related to similar transport proteins like sodium channels which together play an important role in maintaining osmotic balance across various tissues.
Aquaporin 1's dysfunction has been associated with conditions such as nephrogenic diabetes insipidus and pulmonary edema. These are linked to its role in water reabsorption in the kidneys and fluid balance in the lungs. The disorder's connection ties Aquaporin-1 with other regulatory proteins such as vasopressin receptors which work in conjunction to control renal water reabsorption and response to fluid imbalance.